Bioassay of 2,4-dinitrotoluene for possible carcinogenicity.

Bioassay of 2,4-dinitrotoluene for possible carcinogenicity by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

A bioassay of practical-grade 2,4-dinitrotoluene for possible carcinogenicity was conducted using Fische 34r4 rats and B6C3F1 mice. 2,4-Dinitrotoluene was administere idn the feed, at either of two concentrations, to groups of 50 male and 50 femal e animal osf each. Get this from a library.

Bioassay of 2,4-dinitrotoluene for possible carcinogenicity. [National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.]. A bioassay of 2,4-diaminotoluen foer possible carcinogenicit ways conducted by administerin thge test chemica iln feed to F rats and B6C3F1 mice.

Groups of 5 rat0 osf eac seh werx e administere 2,4-diatninod ­ toluene at one of tw doseso, initially either 12 5 or 25 ppm0, for 40 weeks. Becaus of excessive e depressio in thn amoune t o f mean. Bioassay of 2,4-dinitrotoluene for possible carcinogenicity (OCoLC) Material Type: Document, Government publication, National government publication, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: National Cancer Institute (U.S.).

Division of Cancer Cause and Prevention. Bioassay of 2,4-diaminotoluene for possible carcinogenicity. Bethesda, Md.: Dept.

of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program.

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Division. 2,4-Dinitrotoluene: Target Organs and Levels of Evidence for TR Bioassay of 2,4-Dinitrotoluene for Possible Carcinogenicity (CASRN ) Chemical (Study Title).

A bioassay of practical-grade 2,4-dinitrotoluene for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice.

2,4-Dinitrotoluene was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. Long-Term Carcinogenicity. 2-Year (Dosed-Feed) (C) Completed. TR (NIH Number: ) (Peer Review Approval 01/18/A) Bioassay of 2,4-Dinitrotoluene for Possible Carcinogenicity (CASRN ) Rats: F/N; Mice: B6C3F1; Carcinogenesis Results.

Male Rats Positive ; Female Rats Positive ; Male Mice Negative. 2,4-Dinitrotoluene. Uses The predominant use of 2,4-dinitrotoluene is as an intermediate in the manufacture of polyurethanes.

(1) 2,4-Dinitrotoluene is also used for the production of explosives, for which it is a gelatinizing and waterproofing agent. Other applications include uses as an intermediate in dye processes and in smokeless gunpowders.

Rats fed 2,4-dinitrotoluene (2,4-DNT) throughout a 2-year carcinogenicity study developed statistically significant incidences of subcutaneous fibromas and mammary fibroadenomas and low incidences of hepatocellular carcinomas and subcutaneous fibrosarcomas which were not statistically significant.

2,4-Dinitrotoluene (2,4-DNT) was examined for its ability to produce lung tumors in strain A mice. Its tissue distribution and elimination in this mouse strain were also determined. At total doses of, or mg/kg, 2,4-DNT did not produce an increase in Cited by: "Bioassay of 2,4-Dinitrotoluene for Possible Carcinogenicity" U.S.

Department of Health, Education and Welfare, Public Health Service, National Institutes of Health,DHEW Publ. (NIH)NTIS Publ. PB ELSEVIER Journal of Hazardous Materials 49 () JOURNALOF HAZARDOUS MATERIALS Aerobic biodegradation of 2,4-dinitrotoluene, aminonitrotoluene isomers, and 2,4-diaminotoluene D.L.

Freedman a' *, R.S. Shanley b, R.J. Scholze b a Department of Civil Engineering, University of Illinois at Urbana -Champaign, Urbana, IL USA U.S.

Army Construction Engineering Research Cited by: BIOASSAY OF ANTHRANILIC ACID FOR POSSIBLE CARCINOGENICITY CAS NO. [National Cancer Institute] on *FREE* shipping on qualifying offers. US Department of Health National Cancer Institute Carcinogenesis Technical Report no.

4to wraps. 92p. Light depository library markings. National Cancer Institute USABioassay of 2,4-dinitrotoluene for possible carcinogenicity Carcinogenesis technical report series (No. 54) () CAS No.

Cited by: Bioassay of 2,4,5-trimethylaniline for possible carcinogenicity Item Preview Bioassay of 2,4,5-trimethylaniline for possible carcinogenicity by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Publication date Topics. 2,4-Dinitrotoluene is commercially available as a purified isomer or as a component of DNT mixtures.

This substance can be produced by a two-step nitration of toluene in a closed system process producing a mixture, the commercial or technical grade, of approximately 80% ratios of 2,4-dinitrotoluene and 20% of 2, Size: KB. 2,4-dinitrotoluene is a dinitrotoluene in which the methyl group is ortho to one of the nitro groups and para to the other.

It is the most common isomer of dinitrotoluene. Heated yellow liquid. Solidifies if allowed to cool.

Insoluble in water and more dense than water. Toxic by skin absorption, inhalation and ingestion. Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. () Reproducibility of microbial mutagenicity assays. Bioassay of 4-aminonitrophenol for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: National Cancer Institute (U.S.).

Division of Cancer Cause and Prevention. OCLC Number: Notes: "CAS no. " Description.Sigma-Aldrich offers a number of 2,4-Dinitrotoluene products. View information & documentation regarding 2,4-Dinitrotoluene, including CAS, MSDS & more.Search for books, ebooks, and physical Bioassay of diazinon for possible carcinogenicity Published: () Bioassay of piperonyl butoxide for possible carcinogenicity Published: () Bioassay of malaoxon for possible carcinogenicity Published: ().